The River Cree in Newton Stewart has burst its banks with some residents of the town evacuated from low-lying properties.
More than 20 warnings have been issued for Tayside, while residents in the Dumfries and Galloway, Aberdeenshire and Central areas have also been warned of flooding.
Dumfries and Galloway Council has cautioned of the risk of flooding to land and property from rivers in the area, which is expected to result in widespread disruption to travel and infrastructure.
Locations particularly at risk include the Cree valley, the Nith valley and smaller waterways around the Galloway hills. Peak water levels were expected to occur from this morning onwards.
Some residents were evacuated last night from low-lying properties in Newton Stewart in a pre-emptive operation ahead of expected flooding from the River Cree.
The council has also cautioned that flooding at the Whitesands area of Dumfries is predicted to exceed levels of flooding seen in the area in 2009, 2013 and 1982.